Nuclear DNA damages generated by reactive oxygen molecules (ROS) under oxidative stress and their relevance to human cancers, including ionizing radiation-induced neoplasia part II: Relation between ROS-induced DNA damages and human cancer
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چکیده
منابع مشابه
Editorial: Radiation-induced and oxidative DNA damages
The study of DNA lesions and changes, produced by interaction with UV or ionizing radiation and by the effects of oxidative stress, is a multidisciplinary research field in life sciences that has yelded exciting discoveries in the last few decades. The importance of this study is clearly enhanced by its strong societal impact, because of the connections of DNA lesions with carcinogenetic proces...
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Ionizing radiation induces clusters of DNA damages--oxidized bases, abasic sites and strand breaks--on opposing strands within a few helical turns. Such damages have been postulated to be difficult to repair, as are double strand breaks (one type of cluster). We have shown that low doses of low and high linear energy transfer (LET) radiation induce such damage clusters in human cells. In human ...
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Clustered DNA damages-two or more closely spaced damages (strand breaks, abasic sites, or oxidized bases) on opposing strands-are suspects as critical lesions producing lethal and mutagenic effects of ionizing radiation. However, as a result of the lack of methods for measuring damage clusters induced by ionizing radiation in genomic DNA, neither the frequencies of their production by physiolog...
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We sought to understand the relationship between reactive oxygen species (ROS) and the mitochondrial permeability transition (MPT) in cardiac myocytes based on the observation of increased ROS production at sites of spontaneously deenergized mitochondria. We devised a new model enabling incremental ROS accumulation in individual mitochondria in isolated cardiac myocytes via photoactivation of t...
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ژورنال
عنوان ژورنال: Radiation Medicine and Protection
سال: 2020
ISSN: 2666-5557
DOI: 10.1016/j.radmp.2020.11.003